This document provides evidence-based guidance for clinicians in community and hospital settings, as well as providing a reference source on debilitating symptom complexes attributed to ticks (DSCATT) topics. 

This guidance note does not cover co-infections associated with Lyme disease or southern tick-associated rash illness (STARI) (pathogen unknown). Symptoms of STARI and early Lyme disease are similar, with STARI potentially being misdiagnosed as Lyme disease in areas with both lone star ticks and black-legged ticks.